ZIMMERMAN-KORDMANN Martin; REUTTER Werner
Institut für Molekularbiologie und Biochemie Freie Universitt Berlin Arnimallee 22 D-14195 Berlin-Dahlem Germany; Institut für Molekularbiologie und Biochemie Freie Universitt Berlin Arnimallee 22 D-14195 Berlin-Dahlem Germany

【英文摘要】 A crude aqueous extract of Ganoderma lucidum fruiting bodies, LZ, inhibited the growth of eight different tumor cell lines in a dose-dependent manner. Two bioactive fractions, LZ-DN-2-2 and LZ-DW-2-a-3, were obtained from LZ using dialysis combined with anion exchange and gel filtration chromatography. LZ, LZ-DN-2-2 and LZ-DW-2-a-3 induced apoptosis of SW620 cells in a dose-dependent manner, and arrested the tumor cells in the G0 phase of the cell cycle.

【英文關(guān)鍵詞】 Ganoderma lucidum; Apoptosis; Tumor cells

【文獻(xiàn)出處】 食用菌學(xué)報,Acta Edulis Fungi,編輯部郵箱,2006年02期 【DOI】CNKI:SUN:SYJB.0.2006-02-008